BDBM354403 N-(2-ethyl-6-(4- (ethylsulfonyl) piperazin-1- yl)imidazo[1,2- b]pyridazin-3-yl)-4- (4-fluorophenyl)-N- methylthiazol-2- amine::US9796719, Compound 71

SMILES CCc1nc2ccc(nn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCN(CC1)S(=O)(=O)CC

InChI Key InChIKey=TXDSWGQPAPFVMW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354403   

LigandPNGBDBM354403(N-(2-ethyl-6-(4- (ethylsulfonyl) piperazin-1- yl)i...)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
US Patent

TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM354403(N-(2-ethyl-6-(4- (ethylsulfonyl) piperazin-1- yl)i...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound IC50 values are determined in a fluorescent hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using the fluorogenic autotax...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
US Patent