BDBM354429 1-(2-ethyl-3-((4-(4- fluorophenyl) thiazol-2- yl)(methyl)amino) imidazo[1,2- b]pyridazin-6-yl)- N-(2- hydroxyethyl) piperidine-4- carboxamide::US9796719, Compound 97

SMILES CCc1nc2ccc(nn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCC(CC1)C(=O)NCCO

InChI Key InChIKey=PSWHZPFOFSAYOU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354429   

LigandPNGBDBM354429(US9796719, Compound 97 | 1-(2-ethyl-3-((4-(4- fluo...)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
US Patent

TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM354429(US9796719, Compound 97 | 1-(2-ethyl-3-((4-(4- fluo...)
Affinity DataIC50: 5.05E+3nMAssay Description:Compound IC50 values are determined in a fluorescent hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using the fluorogenic autotax...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
US Patent