BDBM35554 thiophene scaffold, 21
SMILES CC(C)N(C(=O)[C@H]1CC[C@H](C)CC1)c1cc(sc1C(O)=O)-c1ccccc1
InChI Key InChIKey=RZXQBIKGWSLVEK-JCNLHEQBSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 35554
Affinity DataIC50: 9nMpH: 7.5 T: 23°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMpH: 7.5 T: 23°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMpH: 7.5 T: 23°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
Affinity DataIC50: >500nMpH: 7.5 T: 23°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of HCV genotype 1b J4 NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
Affinity DataKd: 427nMAssay Description:Inhibition of HCV NS5B polymerase L419M mutantMore data for this Ligand-Target Pair
Affinity DataKd: 33nMAssay Description:Inhibition of HCV NS5B polymerase M414T mutantMore data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Idenix Sarl, An Msd
Curated by ChEMBL
Idenix Sarl, An Msd
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMpH: 7.5 T: 23°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair