BDBM355897 1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7- isopropylpyrazolo[1, 5-a]pyrimidin-6- yl)urea::US10442808, Example 21::US9815842, Example 21

SMILES CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12

InChI Key InChIKey=GSQOTVHUYJQPDR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 355897   

LigandPNGBDBM355897(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Affinity DataIC50:  0.00300nMAssay Description:IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM355897(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Affinity DataIC50:  0.00300nMAssay Description:The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM355897(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of MALT1 in human whole blood assessed as reduction in PMA//anti-CD28 antibody-induced IL2 level pre-incubated for 1 hrs before stimulatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM355897(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Affinity DataIC50:  140nMAssay Description:Inhibition of MALT1 in PMA-stimulated human Jurkat T cells assessed as reduction in IL2 level pretreated for 30 mins followed by PMA-stimulation meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM355897(1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...)
Affinity DataIC50:  3nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed