BDBM355969 (S)-1-(5-chloro-6- (difluoromethoxy) pyridin-3-yl)-3-(2- chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-a]pyrimidin-6- yl)urea::US10442808, Example 93::US9815842, Example 93

SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(OC(F)F)c(Cl)c2)cnc2cc(Cl)nn12

InChI Key InChIKey=YZPQIGOQVAFXSC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355969   

LigandPNGBDBM355969(US9815842, Example 93 | (S)-1-(5-chloro-6- (difluo...)
Affinity DataIC50: 0.00100nMAssay Description:IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
US Patent

LigandPNGBDBM355969(US9815842, Example 93 | (S)-1-(5-chloro-6- (difluo...)
Affinity DataIC50: 0.00100nMAssay Description:The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent