BDBM35651 pyrimidylpyrrole, 10d

SMILES Cc1cccc([C@@H](CO)NC(=O)c2cc(-c3nc(Nc4ccccc4)ncc3C)c[nH]2)c1

InChI Key InChIKey=UOENDEBKABBLDM-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 35651   

TargetMitogen-activated protein kinase 1(Human)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 35651BDBM35651(pyrimidylpyrrole, 10d)
Affinity DataKi: <2nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 35651BDBM35651(pyrimidylpyrrole, 10d)
Affinity DataKi:  26nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 35651BDBM35651(pyrimidylpyrrole, 10d)
Affinity DataKi:  45nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2009
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 35651BDBM35651(pyrimidylpyrrole, 10d)
Affinity DataKi:  69nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2009
Entry Details Article
PubMed