BDBM357100 5-(3-chloro-2,6-difluorophenyl)-2-((5S,9S)-15-fluoro-24- ((methoxycarbonyl)amino)-5-methyl-4-oxo-3-aza-1(2,4)-pyridina-2(1,2)- benzenacyclononaphane-9-yl)pyridine 1-oxide::US10214512, Example 76-b

SMILES COC(=O)Nc1ccc-2c(NC(=O)[C@@H](C)CCC[C@@H](c3cc-2ncc3F)c2ccc(c[n+]2[O-])-c2c(F)ccc(Cl)c2F)c1

InChI Key InChIKey=GNEYFEXMAZDVQB-LPHOPBHVSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357100   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357100(5-(3-chloro-2,6-difluorophenyl)-2-((5S,9S)-15-fluo...)
Affinity DataKi:  1.37nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetKallikrein-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357100(5-(3-chloro-2,6-difluorophenyl)-2-((5S,9S)-15-fluo...)
Affinity DataKi:  1.5nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent