BDBM357226 (Z)-5-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)-2-(25-fluoro-4-oxo -11H-3-aza-1(2,4)-imidazola-2(1,2)-benzenacyclononaphane-9-yl)pyridine 1-oxide::US10214512, Example 161

SMILES [O-][n+]1cc(ccc1C1CCCCC(=O)Nc2ccc(F)cc2-c2nc1c[nH]2)-c1c(F)c(Cl)ccc1-n1cnnn1

InChI Key InChIKey=RTTRNHBUOIYTEB-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357226   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 357226BDBM357226(US10214512, Example 161 | (Z)-5-(3-chloro-2-fluoro...)
Affinity DataKi:  0.550nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetKallikrein-1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 357226BDBM357226(US10214512, Example 161 | (Z)-5-(3-chloro-2-fluoro...)
Affinity DataKi:  1.35nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent