BDBM357736 MW-01-157/(I-207)::US10214530, Example 25

SMILES CCCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O

InChI Key InChIKey=CRJSCQHFVZPKAE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 357736   

TargetTryptophan 5-hydroxylase 1(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM357736(MW-01-157/(I-207) | US10214530, Example 25)
Affinity DataIC50:  350nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandPNGBDBM357736(MW-01-157/(I-207) | US10214530, Example 25)
Affinity DataIC50:  20nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed

TargetTryptophan 5-hydroxylase 1(Human)
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin

US Patent
LigandPNGBDBM357736(MW-01-157/(I-207) | US10214530, Example 25)
Affinity DataIC50:  350nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed

TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandPNGBDBM357736(MW-01-157/(I-207) | US10214530, Example 25)
Affinity DataIC50:  20nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent