BDBM357744 KM-05-80/(I-1)::US10214530, Example 1

SMILES O=c1[nH]c(=O)n(C2CC2)c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c12

InChI Key InChIKey=GLUWCNQLKSIYKQ-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 357744   

TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357744BDBM357744(KM-05-80/(I-1) | US10214530, Example 1)
Affinity DataIC50: 70nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357744BDBM357744(KM-05-80/(I-1) | US10214530, Example 1)
Affinity DataIC50: 70nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Max Delbruck Center

US Patent
LigandChemical structure of BindingDB Monomer ID 357744BDBM357744(KM-05-80/(I-1) | US10214530, Example 1)
Affinity DataIC50: 850nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTryptophan 5-hydroxylase 1(Human)
Max Delbruck Center

US Patent
LigandChemical structure of BindingDB Monomer ID 357744BDBM357744(KM-05-80/(I-1) | US10214530, Example 1)
Affinity DataIC50: 850nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)