BDBM357753 KM-05-174/(I-205)::US10214530, Example 22

SMILES CCn1c(=O)[nH]c(=O)c2c1nc(Cc1nc3cc(F)c(N4CCOCC4)cc3[nH]1)n2Cc1ccccc1

InChI Key InChIKey=MCAYBYDMBYIYAE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357753   

TargetTryptophan 5-hydroxylase 2(Human)
Max Delbruck Center

US Patent
LigandChemical structure of BindingDB Monomer ID 357753BDBM357753(KM-05-174/(I-205) | US10214530, Example 22)
Affinity DataIC50: 60nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 1(Human)
Max Delbruck Center

US Patent
LigandChemical structure of BindingDB Monomer ID 357753BDBM357753(KM-05-174/(I-205) | US10214530, Example 22)
Affinity DataIC50: 1.96E+3nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent