BDBM357754 KM-05-60/(I-10)::US10214530, Example 10

SMILES Cn1c(=O)[nH]c(=O)c2c1nc(Cc1nc3cc(NC(=O)CC[C@H](N)C(=O)O)ccc3[nH]1)n2Cc1ccccc1

InChI Key InChIKey=YQQGCBNTUKQEBJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 357754   

TargetTryptophan 5-hydroxylase 2(Human)
Max Delbruck Center

US Patent
LigandChemical structure of BindingDB Monomer ID 357754BDBM357754(KM-05-60/(I-10) | US10214530, Example 10)
Affinity DataIC50: 170nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Max Delbruck Center

US Patent
LigandChemical structure of BindingDB Monomer ID 357754BDBM357754(KM-05-60/(I-10) | US10214530, Example 10)
Affinity DataIC50: 170nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357754BDBM357754(KM-05-60/(I-10) | US10214530, Example 10)
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 1(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357754BDBM357754(KM-05-60/(I-10) | US10214530, Example 10)
Affinity DataIC50: 2.22E+3nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent