BDBM357849 US10214535, Example 9::[(2S,5R)-5-[(4-methylpyridin- 2-yl)oxy]-1-{[2-(2H-1,2,3- triazol-2-yl)phenyl]carbonyl} piperidin-2-yl]methanol

SMILES COc1ccnc(O[C@@H]2CC[C@@H](CO)N(C2)C(=O)c2ccccc2-n2nccn2)c1

InChI Key InChIKey=WMGHBIXSXYHPHX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357849   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357849([(2S,5R)-5-[(4-methylpyridin- 2-yl)oxy]-1-{[2-(2H-...)
Affinity DataIC50: 68nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357849([(2S,5R)-5-[(4-methylpyridin- 2-yl)oxy]-1-{[2-(2H-...)
Affinity DataIC50: 9.89E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent