BDBM357854 2-{[(3R,6S)-(hydroxymethyl)- 1-{[2-(trifluoromethoxy)phenyl] carbonyl}piperidin-3-yl]oxy}-3- methoxypyridine-4-carbonitrile::US10214535, Example 14

SMILES COc1c(O[C@@H]2CC[C@@H](CO)N(C2)C(=O)c2ccccc2OC(F)(F)F)nccc1C#N

InChI Key InChIKey=MIMZTEGKVSOVHL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357854   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357854(2-{[(3R,6S)-(hydroxymethyl)- 1-{[2-(trifluorometho...)
Affinity DataIC50: 14nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357854(2-{[(3R,6S)-(hydroxymethyl)- 1-{[2-(trifluorometho...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent