BDBM357856 2-{[(3R,6S)-6-(1-hydrox-1- methylethyl)-1-{[2-(2H-1,2,3- triazol-2-yl)phenyl]carbonyl} piperidin-3-yl]oxy}-3- methylpyridine-4-carbonitrile::US10214535, Example 16

SMILES Cc1c(O[C@@H]2CC[C@H](N(C2)C(=O)c2ccccc2-n2nccn2)C(C)(C)O)nccc1C#N

InChI Key InChIKey=OOIHUOJXYVFAOR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357856   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357856(2-{[(3R,6S)-6-(1-hydrox-1- methylethyl)-1-{[2-(2H-...)
Affinity DataIC50: 27nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357856(2-{[(3R,6S)-6-(1-hydrox-1- methylethyl)-1-{[2-(2H-...)
Affinity DataIC50: 1.33E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent