BDBM358941 (6R,8aS)-6-[8-amino-1- (4-{hydroxy[3- (trifluoromethyl)phenyl] methyl}phenyl)imidazo [1,5-a]pyrazin-3- yl]hexahydroindolizin- 3(2H)-one::US10214546, Example 72::US10214546, Example 73

SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(O)c3cccc(c3)C(F)(F)F)c12)[C@@H]1CC[C@H]2CCC(=O)N2C1

InChI Key InChIKey=UGXVPGLRRBABNW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 358941   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM358941(US10214546, Example 73 | (6R,8aS)-6-[8-amino-1- (4...)
Affinity DataIC50: 0.410nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM358941(US10214546, Example 73 | (6R,8aS)-6-[8-amino-1- (4...)
Affinity DataIC50: 20.4nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent