BDBM358978 (6R,8aS)-6-[8-amino-1- (4-{(1R)-1-hydroxy-1- [3-(2,2,2-trifluoro-1,1- dimethylethyl)phenyl] ethyl}phenyl)imidazo[1, 5-a]pyrazin-3- yl]hexahydroindolizin- 3(2H)-one::US10214546, Example 110

SMILES C[C@@](O)(c1ccc(cc1)-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12)c1cccc(c1)C(C)(C)C(F)(F)F

InChI Key InChIKey=DGJCIQZTDCHFES-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358978   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM358978((6R,8aS)-6-[8-amino-1- (4-{(1R)-1-hydroxy-1- [3-(2...)
Affinity DataIC50: 0.950nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent