BDBM359078 (6R,8aS)-6-[8-amino-1- (4-{1-[3- (difluoromethyl)phenyl]- 2,2,2-trifluoro-1- hydroxyethyl}-2- methoxyphenyl)imidazo [1,5-a]pyrazin-3- yl]hexahydroindolizin- 3(2H)-one::US10214546, Example 210::US10214546, Example 211

SMILES COc1cc(ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12)C(O)(c1cccc(c1)C(F)F)C(F)(F)F

InChI Key InChIKey=RSTYONBUOYEVMN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 359078   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359078(US10214546, Example 211 | (6R,8aS)-6-[8-amino-1- (...)
Affinity DataIC50: 0.600nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359078(US10214546, Example 211 | (6R,8aS)-6-[8-amino-1- (...)
Affinity DataIC50: 67nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent