BDBM359516 4-(1-(2-chloro-6-(1- cyanocyclobutyl) benzoyl)-6-(4-methyl-3- oxopiperazine-1- carbonyl)-4,5,6,7- tetrahydro-1H- indazol-3-yl)-3- fluorobenzoic acid::US10221142, Example 15A-A::US10221142, Example 15A-B

SMILES CN1CCN(CC1=O)C(=O)C1CCc2c(C1)n(nc2-c1ccc(cc1F)C(O)=O)C(=O)c1c(Cl)cccc1C1(CCC1)C#N

InChI Key InChIKey=KLMRZRMVCHOJPP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 359516   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 359516BDBM359516(US10221142, Example 15A-B | 4-(1-(2-chloro-6-(1- c...)
Affinity DataIC50: 4.40nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 359516BDBM359516(US10221142, Example 15A-B | 4-(1-(2-chloro-6-(1- c...)
Affinity DataIC50: 625nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent