BDBM359518 4-(1-(2-chloro-6- cyclopropylbenzoyl)- 6-(3- methoxyazetidine-1- carbonyl)-4,5,6,7- tetrahydro-1H- indazol-3-yl)-2- methylbenzoic acid::US10221142, Example 16A-B

SMILES COC1CN(C1)C(=O)C1CCc2c(C1)n(nc2-c1ccc(C(O)=O)c(C)c1)C(=O)c1c(Cl)cccc1C1CC1

InChI Key InChIKey=GGAAHPAXRWIQDY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359518   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 359518BDBM359518(4-(1-(2-chloro-6- cyclopropylbenzoyl)- 6-(3- metho...)
Affinity DataIC50: 5.20nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
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Date in BDB:
10/20/2019
Entry Details
US Patent