BDBM359805 US9822103, Example 65::rac-(3aS,8bS) N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3a-methyl-5-(6-(piperazin-1-yl)pyridin-3-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-7-carboxamide

SMILES Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(N4CCNCC4)nc3)c3c(c2)[C@@H]2CCC[C@]2(C)O3)c(=O)[nH]1

InChI Key InChIKey=TXIOLVXTXNTUBW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359805   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 359805BDBM359805(rac-(3aS,8bS) N-((4,6-Dimethyl-2-oxo-1,2-dihydropy...)
Affinity DataIC50: 500nMAssay Description:EZH2 Histone Methyl Transferase Assay: The effectiveness of compounds of the present invention as inhibitors of histone methyl transferases can be r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent