BDBM359818 N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-(6-(piperazin-1-yl)pyridin-3-yl)-3H-spiro[benzofuran-2,1′-cyclopentane]-5-carboxamide::US9822103, Example 72

SMILES Cc1cc(C)c(CNC(=O)c2cc3c(c(-c4ccc(N5CCNCC5)nc4)c2)OC2(CCCC2)C3)c(=O)[nH]1

InChI Key InChIKey=KSVVBVJVYLNLGV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359818   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 359818BDBM359818(N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 500nMAssay Description:EZH2 Histone Methyl Transferase Assay: The effectiveness of compounds of the present invention as inhibitors of histone methyl transferases can be r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent