BDBM359839 2-Methyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-7-(6-(piperazin-1-yl)pyridin-3-yl)-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-5-carboxamide, 2 TFA::US9822103, Example 87

SMILES C=C(C)C1(C)Cc2cc(C(=O)NCc3c(CCC)cc(C)[nH]c3=O)cc(-c3ccc(N4CCNCC4)nc3)c2O1

InChI Key InChIKey=ILUAVWWSFZDAMP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359839   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 359839BDBM359839(2-Methyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropy...)
Affinity DataIC50: 500nMAssay Description:EZH2 Histone Methyl Transferase Assay: The effectiveness of compounds of the present invention as inhibitors of histone methyl transferases can be r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent