BDBM359971 N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl}-2-cyclopropylfuro[2,3-b]pyridine-6-carboxamide::US9822124, Example 70

SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2cc(oc2n1)C1CC1

InChI Key InChIKey=MMCCPLRYOIVJBL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 359971   

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandPNGBDBM359971(US9822124, Example 70 | N-{4-[(3S,5R)-3-Amino-5-me...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandPNGBDBM359971(US9822124, Example 70 | N-{4-[(3S,5R)-3-Amino-5-me...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM359971(US9822124, Example 70 | N-{4-[(3S,5R)-3-Amino-5-me...)
Affinity DataIC50: 100nMAssay Description:Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent