BDBM359984 N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl}-2-(cis-2-methylcyclopropyl)furo[2,3-b]pyridine-6-carboxamide (Example 75) and N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl}-2-(trans-2-methylcyclopropyl)furo[2,3-b]pyridine-6-carboxamide (Example 76)::US9822124, Example 76

SMILES C[C@H]1CC1c1cc2ccc(nc2o1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1

InChI Key InChIKey=FDYLHTJKBORSNX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 359984   

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandPNGBDBM359984(US9822124, Example 76 | N-{4-[(3S,5R)-3-Amino-5-me...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandPNGBDBM359984(US9822124, Example 76 | N-{4-[(3S,5R)-3-Amino-5-me...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays 20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM359984(US9822124, Example 76 | N-{4-[(3S,5R)-3-Amino-5-me...)
Affinity DataIC50: 100nMAssay Description:Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent