BDBM360338 4-(2-amino-3H-benzo[d]imidazol-4-yl)-3-(2H-tetrazol-5-yl)benzene-1,2-disulfonamide::US10221163, Example 1::US10544130, Example 1

SMILES Nc1nc2cccc(-c3ccc(c(c3-c3nn[nH]n3)S(N)(=O)=O)S(N)(=O)=O)c2[nH]1

InChI Key InChIKey=VVGDNPGVZIEQAP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 360338   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360338(US10221163, Example 1 | 4-(2-amino-3H-benzo[d]imid...)
Affinity DataIC50: 0.0850nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360338(US10221163, Example 1 | 4-(2-amino-3H-benzo[d]imid...)
Affinity DataIC50: 0.0850nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360338(US10221163, Example 1 | 4-(2-amino-3H-benzo[d]imid...)
Affinity DataIC50: 0.0850nMAssay Description:Inhibition of NDM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360338(US10221163, Example 1 | 4-(2-amino-3H-benzo[d]imid...)
Affinity DataIC50: 0.264nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM360338(US10221163, Example 1 | 4-(2-amino-3H-benzo[d]imid...)
Affinity DataIC50: 0.264nMAssay Description:Inhibition of VIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Xihua University

Curated by ChEMBL
LigandPNGBDBM360338(US10221163, Example 1 | 4-(2-amino-3H-benzo[d]imid...)
Affinity DataIC50: 0.264nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360338(US10221163, Example 1 | 4-(2-amino-3H-benzo[d]imid...)
Affinity DataIC50: 0.581nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360338(US10221163, Example 1 | 4-(2-amino-3H-benzo[d]imid...)
Affinity DataIC50: 0.581nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent