BDBM360421 (1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-::US10221162, Example 759.0::US9845310, Example 760.0

SMILES COc1cccc(-c2nnc(NS(=O)(=O)[C@@H](C)[C@@H](c3ncc(C)cn3)N3CC(OC)C3)n2-c2c(OC)cccc2OC)n1

InChI Key InChIKey=ZURKCDFHOPDMMB-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 360421   

TargetApelin receptor(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 360421BDBM360421((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  0.0950nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 360421BDBM360421((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  0.360nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 360421BDBM360421((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  6.80nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 360421BDBM360421((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Affinity DataEC50:  6.80nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent