BDBM360451 (1S,2S)-2-(4-methoxyphenyl)-N-((5- (3-methoxyphenyl)isoquinolin-8- yl)methyl)cyclopropanecarboxamide::US9828369, Example 106::US9828369, Example 23

SMILES COc1ccc(cc1)C1CC1C(=O)NCc1ccc(-c2cccc(OC)c2)c2ccncc12

InChI Key InChIKey=JYIFLWOQDGVZHY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 360451   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360451(US9828369, Example 23 | US9828369, Example 106 | (...)
Affinity DataIC50: 537nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360451(US9828369, Example 23 | US9828369, Example 106 | (...)
Affinity DataIC50: 9.96E+3nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent