BDBM360452 (cis)-2-(4-methoxyphenyl)-N-((5-(3- methoxyphenyl)isoquinolin-8- yl)methyl)cyclopropanecarboxamide (mixture of 2 isomers)::US9828369, Example 24

SMILES COc1ccc(cc1)[C@@H]1C[C@@H]1C(=O)NCc1ccc(-c2cccc(OC)c2)c2ccncc12

InChI Key InChIKey=JYIFLWOQDGVZHY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 360452   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360452((cis)-2-(4-methoxyphenyl)-N-((5-(3- methoxyphenyl)...)
Affinity DataIC50: 589nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent