BDBM360543 N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)spiro[2.5]octane-1- carboxamide::US9828369, Example 100

SMILES COc1cccc(c1)-c1ccc(CNC(=O)C2CC22CCCCC2)c2cnccc12

InChI Key InChIKey=XJEGKCQCXDJWIP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 360543   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360543(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)sp...)
Affinity DataIC50:  243nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM360543(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)sp...)
Affinity DataIC50:  4.77E+3nMAssay Description:Inhibition of MGAT2 (unknown origin) by CPM assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360543(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)sp...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 cell membranes assessed as triolein formation by LC/MS/MS analysis using oleoyl-CoA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed