BDBM360569 (R/S)-2-(3-fluoro-4- (trifluoromethyl)phenyl)-N-((5-(3- methoxyphenyl)isoquinolin-8- yl)methyl)butanamide (mixture of 2 enantiomers)::US9828369, Example 126

SMILES CC[C@H](C(=O)NCc1ccc(-c2cccc(OC)c2)c2ccncc12)c1ccc(c(F)c1)C(F)(F)F

InChI Key InChIKey=XILRZKYXWQQULE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 360569   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360569((R/S)-2-(3-fluoro-4- (trifluoromethyl)phenyl)-N-((...)
Affinity DataIC50: 373nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent