BDBM360614 N-[(11bR)-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinolin-9-yl]-2-(trifluoromethyl)pyridine-4-carboxamide::US9828374, Example 1

SMILES FC(F)(F)c1cc(ccn1)C(=O)Nc1ccc2[C@@H]3CNCCN3CCc2c1

InChI Key InChIKey=GJMPUGCVGICJRX-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 360614   

TargetTrace amine-associated receptor 1(Rat)
Hoffmann-La Roche

US Patent
LigandPNGBDBM360614(US9828374, Example 1 | N-[(11bR)-2,3,4,6,7,11b-hex...)
Affinity DataKi:  121nMAssay Description:The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetTrace amine-associated receptor 1(Mouse)
Hoffmann-La Roche

US Patent
LigandPNGBDBM360614(US9828374, Example 1 | N-[(11bR)-2,3,4,6,7,11b-hex...)
Affinity DataKi:  199nMAssay Description:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent