BDBM360626 (R)-N-(5-(2,2,2-trifluoroethoxy)pyrimidin-2-yl)-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinolin-9-amine::US9828374, Example 13

SMILES FC(F)(F)COc1cnc(Nc2ccc3[C@@H]4CNCCN4CCc3c2)nc1

InChI Key InChIKey=WWWVDCHMQNBRCN-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 360626   

TargetTrace amine-associated receptor 1(Rat)
Hoffmann-La Roche

US Patent
LigandPNGBDBM360626(US9828374, Example 13 | (R)-N-(5-(2,2,2-trifluoroe...)
Affinity DataKi:  7.80nMAssay Description:The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent

TargetTrace amine-associated receptor 1(Mouse)
Hoffmann-La Roche

US Patent
LigandPNGBDBM360626(US9828374, Example 13 | (R)-N-(5-(2,2,2-trifluoroe...)
Affinity DataKi:  11.9nMAssay Description:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
US Patent