BDBM360925 (R)-di-tert-butyl (3-(2-(N,N- bis(4-methoxybenzyl)sulfamoyl)- 4-iodo-3-(2-(4-methoxybenzyl)- 2H-tetrazol-5- yl)phenylsulfonamido)propane- 1,2-diyl)dicarbamate::US10221163, Example 81::US10544130, Example 81

SMILES COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2c(ccc(I)c2-c2nnn(Cc3ccc(OC)cc3)n2)S(=O)(=O)NC[C@@H](CNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)cc1

InChI Key InChIKey=MPKFPGZSQMILTQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 360925   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360925(US10221163, Example 81 | (R)-di-tert-butyl (3-(2-(...)
Affinity DataIC50: 0.0290nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360925(US10221163, Example 81 | (R)-di-tert-butyl (3-(2-(...)
Affinity DataIC50: 0.0290nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360925(US10221163, Example 81 | (R)-di-tert-butyl (3-(2-(...)
Affinity DataIC50: 0.135nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360925(US10221163, Example 81 | (R)-di-tert-butyl (3-(2-(...)
Affinity DataIC50: 0.135nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360925(US10221163, Example 81 | (R)-di-tert-butyl (3-(2-(...)
Affinity DataIC50: 0.191nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360925(US10221163, Example 81 | (R)-di-tert-butyl (3-(2-(...)
Affinity DataIC50: 0.191nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent