BDBM360947 (3R,3aR, 6S,6aR)-6-(4-(2- aminobenzo[d] thiazol-4-yl)-2- sulfamoyl-3-(1H- tetrazol-5-yl)phenyl- sulfonamido) hexahydrofuro[3,2- b]furan-3-aminium 2,2,2- trifluoroacetate::US10221163, Example 103::US10544130, Example 103

SMILES N[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)NS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nnn[nH]2)c1S(N)(=O)=O

InChI Key InChIKey=AHZFCTJEQMRQJT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 360947   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360947(US10221163, Example 103 | (3R,3aR, 6S,6aR)-6-(4-(2...)
Affinity DataIC50: 0.0290nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360947(US10221163, Example 103 | (3R,3aR, 6S,6aR)-6-(4-(2...)
Affinity DataIC50: 0.0290nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360947(US10221163, Example 103 | (3R,3aR, 6S,6aR)-6-(4-(2...)
Affinity DataIC50: 0.196nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360947(US10221163, Example 103 | (3R,3aR, 6S,6aR)-6-(4-(2...)
Affinity DataIC50: 0.196nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360947(US10221163, Example 103 | (3R,3aR, 6S,6aR)-6-(4-(2...)
Affinity DataIC50: 0.226nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360947(US10221163, Example 103 | (3R,3aR, 6S,6aR)-6-(4-(2...)
Affinity DataIC50: 0.226nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent