BDBM361372 N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-3- (trifluoromethyl)benzo[d] isothiazol-6- amine::US10221172, Example 29

SMILES FC(F)(F)c1nsc2cc(Nc3n[nH]c4ncccc34)ccc12

InChI Key InChIKey=ANVSJEGVZCUEPF-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 361372   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 361372BDBM361372(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-3- (trifluorom...)
Affinity DataEC50:  794nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 361372BDBM361372(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-3- (trifluorom...)
Affinity DataEC50:  794nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 361372BDBM361372(N-(1H-pyrazolo[3,4-b] pyridin-3-yl)-3- (trifluorom...)
Affinity DataEC50:  1.24E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent