BDBM362425 4-{7-amino-3- [(6R,8aS)-3- oxooctahydroindolizin- 6-yl]-1H-pyrazolo[3,4-c] pyridin-1-yl}- 3-(cyclopropyloxy)-N-[4- (trifluoromethyl)pyridin-2-yl] benzamide::US9834554, Example 39

SMILES Nc1nccc2c(nn(-c3ccc(cc3OC3CC3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CC[C@H]2CCC(=O)N2C1

InChI Key InChIKey=JZIUBAXAUPVQAR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 362425   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362425(4-{7-amino-3- [(6R,8aS)-3- oxooctahydroindolizin- ...)
Affinity DataIC50: 2.80nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
US Patent