BDBM362853 (R)-(8-methyl-3-(2- (trifluoromethyl)thiazol-4-yl)- 5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl)(3,4,5- trifluorophenyl)methanone::US9840508, Compound 15

SMILES C[C@H]1N(CCn2c1nnc2-c1csc(n1)C(F)(F)F)C(=O)c1cc(F)c(F)c(F)c1

InChI Key InChIKey=VZMWAYUMGJCBRT-SSDOTTSWSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 362853   

TargetNeuromedin-K receptor(Homo sapiens (Human))
Oged

US Patent
LigandPNGBDBM362853((R)-(8-methyl-3-(2- (trifluoromethyl)thiazol-4-yl)...)
Affinity DataKi:  13nMAssay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Oged

US Patent
LigandPNGBDBM362853((R)-(8-methyl-3-(2- (trifluoromethyl)thiazol-4-yl)...)
Affinity DataKi:  13nMAssay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-K receptor(Homo sapiens (Human))
Oged

US Patent
LigandPNGBDBM362853((R)-(8-methyl-3-(2- (trifluoromethyl)thiazol-4-yl)...)
Affinity DataKi:  3.50E+3nMAssay Description:The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSubstance-P receptor(Homo sapiens (Human))
Oged

US Patent
LigandPNGBDBM362853((R)-(8-methyl-3-(2- (trifluoromethyl)thiazol-4-yl)...)
Affinity DataKi:  2.40E+4nMAssay Description:The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuromedin-K receptor(Homo sapiens (Human))
Oged

US Patent
LigandPNGBDBM362853((R)-(8-methyl-3-(2- (trifluoromethyl)thiazol-4-yl)...)
Affinity DataIC50:  24nMAssay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent