BDBM363028 3-((6-chloro-7-fluoro-1-(2-(3-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl)-2-oxoethyl)-2-methyl-1H-indol-3-yl)thio)-2-fluorobenzoate::US9850203, Compound 2-57::US9850203, Compound 2-58::US9850203, Compound 2-59

SMILES Cc1c(Sc2cccc(C([O-])=O)c2F)c2ccc(Cl)c(F)c2n1CC(=O)N1CCC(O)(C1)C(F)(F)F

InChI Key InChIKey=FNECJYVYHDKZIU-UHFFFAOYSA-M

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 363028   

TargetAutotaxin(Human)
Pharmakea

US Patent
LigandPNGBDBM363028(US9850203, Compound 2-57 | US9850203, Compound 2-5...)
Affinity DataIC50: 500nMAssay Description:ATX activity is assayed in concentrated conditioned media from Hep3B human hepatocellular carcinoma cells by measuring the amount of choline released...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent

TargetAutotaxin(Human)
Pharmakea

US Patent
LigandPNGBDBM363028(US9850203, Compound 2-57 | US9850203, Compound 2-5...)
Affinity DataIC50: 500nMAssay Description:ATX activity is assayed in concentrated conditioned media from Hep3B human hepatocellular carcinoma cells by measuring the amount of choline released...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent

TargetAutotaxin(Human)
Pharmakea

US Patent
LigandPNGBDBM363028(US9850203, Compound 2-57 | US9850203, Compound 2-5...)
Affinity DataIC50: 500nMAssay Description:ATX activity is assayed in concentrated conditioned media from Hep3B human hepatocellular carcinoma cells by measuring the amount of choline released...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent