BDBM364418 US9862688, Compound 5

SMILES Clc1cnc(Nc2cnn(CCN3CCN(CC3)C(=O)CC3C4C[C@@H]5CC(C4)C[C@H]3C5)c2)nc1NCc1cccc(NC(=O)C=C)c1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 364418   

TargetTyrosine-protein kinase JAK3(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364418(US9862688, Compound 5)
Affinity DataIC50: 4.90nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364418(US9862688, Compound 5)
Affinity DataIC50: 94nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364418(US9862688, Compound 5)
Affinity DataIC50: 676nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364418(US9862688, Compound 5)
Affinity DataIC50: 1.11E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364418(US9862688, Compound 5)
Affinity DataIC50: 1.37E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364418(US9862688, Compound 5)
Affinity DataIC50: 1.97E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent