BDBM364420 US9862688, Compound 6

SMILES Clc1cnc(Nc2cnn(c2)C2CCN(CC2)C(=O)CC2[C@H]3CC4C[C@@H](C[C@H]2C4)C3)nc1NCc1cccc(NC(=O)C=C)c1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 364420   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364420(US9862688, Compound 6)
Affinity DataIC50: 1.64nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364420(US9862688, Compound 6)
Affinity DataIC50: 3.86nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364420(US9862688, Compound 6)
Affinity DataIC50: 5.90nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364420(US9862688, Compound 6)
Affinity DataIC50: 38nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364420(US9862688, Compound 6)
Affinity DataIC50: 2.08E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM364420(US9862688, Compound 6)
Affinity DataIC50: 3.18E+3nMAssay Description:The in vitro activity of the compounds described herein in inhibiting JAK3 and other kinases were obtained using an INVITROGEN Select Screening assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent