BDBM364484 (R or S)-N-[5-(2,2-difluoro-1- hydroxyethyl)-2-phenyl-2H- indazol-3-yl]-2-fluoro-5-pyrimidin- 2-yl-4-(trifluoromethyl)benzamide, isomer A::US9862707, Example 58::US9862707, Example 59

SMILES OC(C(F)F)c1ccc2nn(c(NC(=O)c3cc(-c4ncccn4)c(cc3F)C(F)(F)F)c2c1)-c1ccccc1

InChI Key InChIKey=FKUSMPPXJLOXCR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364484   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364484((R or S)-N-[5-(2,2-difluoro-1- hydroxyethyl)-2-phe...)
Affinity DataIC50:  4.90nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364484((R or S)-N-[5-(2,2-difluoro-1- hydroxyethyl)-2-phe...)
Affinity DataIC50:  6.90nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent