BDBM364563 (4bR,6S,8aS,9S)-11-(cyclopropylmethyl)-6- hydroxy-3-methoxy-5,6,7,8-tetrahydro- 9,4b-(epiminoethano)-8a,6- (epoxymethano)phenanthrene-10,15(9H)- dione::US9862726, Compound 33

SMILES COc1ccc2C(=O)[C@H]3N(CC4CC4)CC[C@@]4(C[C@@]5(O)CC[C@@]34OC5=O)c2c1

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364563   

TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM364563(US9862726, Compound 33 | (4bR,6S,8aS,9S)-11-(cyclo...)
Affinity DataKi:  3.35E+3nMAssay Description:Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM364563(US9862726, Compound 33 | (4bR,6S,8aS,9S)-11-(cyclo...)
Affinity DataKi: >2.00E+4nMAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg mem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent