BDBM365097 4-(3-(3-fluoro-4- methoxybenzyl)-3,4-dihydro- 5-oxa-1,2,2a1- triazaacenaphthylen-7-yl)-N- (1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine::US10517878, Compound I-46::US10842799, I-46::US9867833, Compound I-46(S)

SMILES COc1ccc(CC2COc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1F

InChI Key InChIKey=UBFJRUBIZJZSQZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365097   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365097(4-(3-(3-fluoro-4- methoxybenzyl)-3,4-dihydro- 5-ox...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365097(4-(3-(3-fluoro-4- methoxybenzyl)-3,4-dihydro- 5-ox...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365097(4-(3-(3-fluoro-4- methoxybenzyl)-3,4-dihydro- 5-ox...)
Affinity DataIC50: 2.47nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
US Patent