BDBM365122 4-(9-(3-fluoro-4- methoxybenzyl)-8,9- dihydro-7H-6-oxa- 1,2,2a1- triazabenzo[cd]azulen-4- yl)-N-(1-methyl-1H- pyrazol-5-yl)pyrimidin-2- amine::US10517878, Compound I-59::US10842799, I-59::US9867833, Compound I-59(S)

SMILES COc1ccc(CC2CCOc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1F

InChI Key InChIKey=WXPNWZWZWVJSGF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365122   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365122(US9867833, Compound I-59(S) | 4-(9-(3-fluoro-4- me...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365122(US9867833, Compound I-59(S) | 4-(9-(3-fluoro-4- me...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365122(US9867833, Compound I-59(S) | 4-(9-(3-fluoro-4- me...)
Affinity DataIC50: 1.86nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
US Patent