BDBM365150 9-(2-fluoro-4- methoxybenzyl)-6-methyl-4- (2-((1-methyl-1H-pyrazol-5- yl)amino)pyridin-4-yl)-8,9- dihydro-1,2,2a1,6- tetraazabenzo[cd]azulen- 7(6H)-one::US10517878, Compound I-74::US10842799, I-74::US9867833, Compound I-74(S)

SMILES COc1ccc(CC2CC(=O)N(C)c3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)c2)c(F)c1

InChI Key InChIKey=MNSDDHFEXYIPRR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365150   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365150(9-(2-fluoro-4- methoxybenzyl)-6-methyl-4- (2-((1-m...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365150(9-(2-fluoro-4- methoxybenzyl)-6-methyl-4- (2-((1-m...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365150(9-(2-fluoro-4- methoxybenzyl)-6-methyl-4- (2-((1-m...)
Affinity DataIC50: 2.85nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
US Patent