BDBM365184 N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((3-methylisoxazol- 5-yl)methyl)-8,9-dihydro-7H- 6-oxa-1,2,2a1- triazabenzo[cd]azulen-4- yl)pyrimidin-2-amine::US10278975, Compound I-93 R::US11376260, Example I-93S::US9867833, Compound I-93(R)

SMILES Cc1cc(C[C@@H]2CCOc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)on1

InChI Key InChIKey=VPKQELJVDUHMBF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365184   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365184(US9867833, Compound I-93(R) | N-(1-methyl-1H-pyraz...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365184(US9867833, Compound I-93(R) | N-(1-methyl-1H-pyraz...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 6(Human)
Genentech

US Patent
LigandPNGBDBM365184(US9867833, Compound I-93(R) | N-(1-methyl-1H-pyraz...)
Affinity DataIC50: 18.2nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
US Patent