BDBM367203 5-(4-methoxyphenyl)-2-oxo- N-(4-phenylbutyl)-1,3- benzoxazole-3-carboxamide::US10226452, Example 21

SMILES COc1ccc(cc1)-c1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1

InChI Key InChIKey=WXOYFFMUMQVXGO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367203   

TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM367203(5-(4-methoxyphenyl)-2-oxo- N-(4-phenylbutyl)-1,3- ...)
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM367203(5-(4-methoxyphenyl)-2-oxo- N-(4-phenylbutyl)-1,3- ...)
Affinity DataIC50: 68nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent