BDBM367221 N-[4-(4- methoxyphenyl)butyl]-2-oxo- 1,3-benzoxazole-3- carboxamide::US10226452, Example 45

SMILES COc1ccc(CCCCNC(=O)n2c3ccccc3oc2=O)cc1

InChI Key InChIKey=NXIHIAGXLXNKMS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367221   

TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM367221(N-[4-(4- methoxyphenyl)butyl]-2-oxo- 1,3-benzoxazo...)
Affinity DataIC50: 63nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM367221(N-[4-(4- methoxyphenyl)butyl]-2-oxo- 1,3-benzoxazo...)
Affinity DataIC50: 63nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent