BDBM367627 7-chloro-N-((1R,2R)-1-(4- cyclopropoxy-3-fluorophenyl)-1- hydroxy-3-(pyrrolidin-1-yl)propan-2- yl)-1H-benzo[4,5]thieno[2,3- d][1,2]oxazine-4-carboxamide::US10227312, Example 12::US10759769, Example 12

SMILES O[C@@H]([C@@H](CN1CCCC1)NC(=O)C1=NOCc2c1sc1cc(Cl)ccc21)c1ccc(OC2CC2)c(F)c1

InChI Key InChIKey=JNYNMVDASXKMIO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367627   

TargetCeramide glucosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM367627(US10227312, Example 12 | 7-chloro-N-((1R,2R)-1-(4-...)
Affinity DataIC50: 55nMAssay Description:Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetCeramide glucosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM367627(US10227312, Example 12 | 7-chloro-N-((1R,2R)-1-(4-...)
Affinity DataIC50: 55nMAssay Description:This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent